Fundamentals of Mass Spectrometry

Fundamentals of ion mobility spectrometry.

Fundamental questions in ion mobility spectrometry have practical implications for analytical applications in general, and omics in particular, in three respects. (1) Understanding how ion mobility and collision cross section values depend on the collision gas, on the electric field and on temperature is crucial to ascertain their transferability across instrumental platforms. (2) Predicting co...

Fundamentals of Mass Flow Control

Sensor The thermal sensor is designed for quick response, long-term stability, and high reliability. The sensor tube in an Aera mass flow product has a very small diameter and mass to ensure the fastest response to any change in gas flow conditions. Bypass Also known as the flow splitter, the bypass maintains a constant ratio of gas flow through the sensor and main flow path, dividing the gas s...

Fundamentals of matrix-assisted laser desorption/ionization mass spectrometry with pulsed infrared lasers

The fundamental work and current knowledge on the mechanisms of matrix-assisted laser desorption ionization with pulsed infrared lasers is reviewed and discussed, with a special emphasis on the work performed in the laboratory of the authors in the recent past. The role of the different relevant irradiation parameters (laser wavelength, laser pulse duration, irradiated area and laser fluence) a...

Fundamentals of Biomolecule Analysis by Electrospray Ionization Mass Spectrometry: An Instrumental Analysis Laboratory Experiment

www.JCE.DivCHED.org • Vol. 82 No. 1 January 2005 • Journal of Chemical Education 99 Mass Spectrometry (MS) has become one of the premier modern analytical tools for the analysis of molecules of biological interest. The development of electrospray ionization (1) (ESI), a soft ionization technique that allows transfer of fragile biomolecules directly from solution into the gas phase, merited a sh...

Ligand-Exchange and Metal Complexation studied by Mass Spectrometry Fundamentals and applications in analytical chemistry